{"id":142,"date":"2010-04-29T22:28:12","date_gmt":"2010-04-30T03:28:12","guid":{"rendered":"http:\/\/gentropy.org\/blogs\/2010\/04\/29\/intrinsic-stochastic-developmental-variation-in-contributing-to-phenotypic-variance\/"},"modified":"2010-04-29T22:28:16","modified_gmt":"2010-04-30T03:28:16","slug":"intrinsic-stochastic-developmental-variation-in-contributing-to-phenotypic-variance","status":"publish","type":"post","link":"https:\/\/gentropy.org\/blogs\/2010\/04\/29\/intrinsic-stochastic-developmental-variation-in-contributing-to-phenotypic-variance\/","title":{"rendered":"intrinsic stochastic developmental variation in contributing to phenotypic variance"},"content":{"rendered":"<p><a href=\"http:\/\/www.gnxp.com\/wp\/uncategorized\/nature-nurture-and-noise\">Nature, nurture and noise \u00bb Gene Expression<\/a><\/p>\n<blockquote><p>The basic problem with the interpretation above is that it limits \u201cinnate\u201d influences to \u201cgenetic\u201d ones. Just because some trait is not genetic does not mean it is not innate. If we are talking about how the brain gets wired, any number of prenatal environmental factors are known to have large effects. More interestingly, however, and probably a greater source of variance across the population, is intrinsic developmental variation. Wiring the brain is a highly complex procedure, reliant on cellular processes that are, in engineering terms, inherently \u201cnoisy\u201d. Running the programme from the same starting point (a specific genotype) does not generate exactly the same output (the phenotype) every time. The effects of this noise are readily apparent at the anatomical level, when examining the impact of specific mutations, for example. In many cases, the phenotypic consequences are quite variable between genetically identical organisms, or even on two sides of the same brain. (If you want to see direct evidence of such developmental variation, take a directly face-on photograph of yourself, cut it in half and make mirror-image copies of the left and right sides. You will be amazed how different the two resultant faces are).<\/p><\/blockquote>\n","protected":false},"excerpt":{"rendered":"<p>Nature, nurture and noise \u00bb Gene Expression The basic problem with the interpretation above is that it limits \u201cinnate\u201d influences to \u201cgenetic\u201d ones. Just because some trait is not genetic does not mean it is not innate. If we are talking about how the brain gets wired, any number of prenatal environmental factors are known [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[10,11],"tags":[],"class_list":["post-142","post","type-post","status-publish","format-standard","hentry","category-genetics","category-intelligence"],"_links":{"self":[{"href":"https:\/\/gentropy.org\/blogs\/wp-json\/wp\/v2\/posts\/142","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/gentropy.org\/blogs\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/gentropy.org\/blogs\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/gentropy.org\/blogs\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/gentropy.org\/blogs\/wp-json\/wp\/v2\/comments?post=142"}],"version-history":[{"count":1,"href":"https:\/\/gentropy.org\/blogs\/wp-json\/wp\/v2\/posts\/142\/revisions"}],"predecessor-version":[{"id":143,"href":"https:\/\/gentropy.org\/blogs\/wp-json\/wp\/v2\/posts\/142\/revisions\/143"}],"wp:attachment":[{"href":"https:\/\/gentropy.org\/blogs\/wp-json\/wp\/v2\/media?parent=142"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/gentropy.org\/blogs\/wp-json\/wp\/v2\/categories?post=142"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/gentropy.org\/blogs\/wp-json\/wp\/v2\/tags?post=142"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}